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Chinese researchers identify target to develop depression drug using traditional ethnic medicine in Yunnan_我的网站

中国新歌声

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Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province. Photo: Scrrenshot from website
A Chinese research team has identified a new potential target to develop antidepressant drug from Qingyangshen, or Root of Auricledleaf Swallowwort, a traditional ethnic medicinal plant long used in Southwest China's Yunnan Province, according to Kunming University of Science and Technology, Science and Technology Daily reported Sunday.
The team, led by professors Xu Tianrui and Xiang Cheng from the university's School of Life Science and Technology, found that Qingyangshen glycosides, the plant's core active compound, can alleviate depression-related behaviors by simultaneously suppressing inflammation, reducing oxidative damage and stabilizing neurotransmitters in the brain.
The findings were published in the international journal Phytomedicine.
Depression has become a widespread mental health disorder globally, while existing clinical drugs fail to provide effective treatment for more than 30 percent of patients, according to the researchers. Previous studies have established a strong link between chronic inflammation and depression, but existing anti-inflammatory drugs have limited targeting capabilities, underscoring the need for new therapeutic targets and lead compounds.
Qingyangshen, a plant of the Cynanchum genus in the Apocynaceae family, has long been used as a traditional medicine by ethnic groups including the Naxi, Yi and Bai peoples in Yunnan, mainly for treating neurological conditions such as epilepsy and neurasthenia.
The researchers systematically examined the pharmacological effects of Qingyangshen extract and its core active compound, Qingyangshen glycosides. Tests using mouse, zebrafish and fruit fly models repeatedly showed that the compound significantly improved depression-related behaviors induced by inflammation, according to the report.
To identify the compound's target, the team developed a dual-discrimination model for four subtypes of prostaglandin E2 receptors and combined it with AI-powered machine learning. The researchers screened hundreds of G protein-coupled receptors and identified the prostaglandin E2 subtype 4 receptor as the direct target of Qingyangshen glycosides.
Multiple molecular experiments confirmed that the compound binds directly to the receptor and acts as an inhibitory ligand. Further experiments involving animals with the receptor knocked out in the hippocampus showed that the antidepressant effects of Qingyangshen glycosides disappeared completely when the receptor was absent, providing the first in-vivo evidence that the receptor is essential for the compound's therapeutic effects.
An illustration of the research. Photo: Screenshot from the website

An illustration of the research. Photo: Screenshot from the website
The study establishes the prostaglandin E2 subtype 4 receptor as a potential new target for antidepressant drug development and points to a new approach to treating depression through inflammatory pathways. It also identifies Qingyangshen glycosides as a potential lead compound for developing highly targeted anti-inflammatory antidepressants, creating a research chain from ethnic medicinal plants and active compounds to drug targets and new drug development.
Global Times
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原标题：打击“灭绝式”捕捉农业农村部会同多部门整治电捕蚯蚓乱象未来农业农村部将会同有关部门，加大工作力度，持续加强蚯蚓等土壤生物保护。新京报讯（记者田杰雄）近期，农业农村部会同有关部门印发《关于加强野生蚯蚓保护改善土壤生态环境的通知》，组织排查整治非法捕杀野生蚯蚓行为，促进土壤质量和生态环境保护。9月13日，农业农村部科技教育司有关负责人在就相关问题答记者问时指出，近年来，部分地区通过电捕蚯蚓的方式，对野生蚯蚓进行“灭绝式”捕捉，破坏土壤生态环境，且存在安全隐患，为保护耕地质量和生态环境，必须严厉打击电捕野生蚯蚓行为。农业农村部科技教育司有关负责人指出，蚯蚓是土壤生态系统重要物种，通过在土壤中穿行掘穴，可改善土壤团粒结构，提高土壤通气透水性、水资源利用效率等，为植物生长创造良好条件。同时，蚯蚓的取食、消化、排泄等活动，还能加速土壤中有机物质降解，促进土壤物质循环与能量流动，在平衡和稳定土壤生态系统方面发挥着重要作用。近年来，受蚯蚓制成的“地龙干”价格飙升等因素影响，在部分地区出现电捕野生蚯蚓现象，不法分子利用“地龙仪”“电蚯蚓机”等设备，对野生蚯蚓进行“灭绝式”捕捉。这种行为会导致蚯蚓数量急剧下降，破坏土壤生态环境，影响农作物产量，而且有关仪器设备多为非法改装改造，存在安全隐患，还可能致人触电身亡。

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