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科学家发现一种分子可以摧毁小鼠体内最严重的癌症_我的网站

荆轲刺秦王

A | The filming has officially wrapped on Daayra, the much-anticipated next film by Meghna Gulzar. It stars Kareena Kapoor Khan and Prithviraj Sukumaran in key roles. Jointly produced by Junglee Pictures and Pen Studios, the film now enters post-production and is slated for a 2026 theatrical release. The makers shared the update on social media along with the photo of Meghna, Kareena and Prithviraj. They captioned the post as, "#Daayra! It’s a wrap! Months of hard work, creativity, and collaboration have come together to bring this story to life. Immense gratitude to the cast, crew, and everyone who made this journey possible. Onward to the next chapter! In Cinemas 2026" Take a look at the post: View this post on Instagram A post shared by Junglee Pictures (@jungleepictures) Daayra is a gripping investigative crime thriller that explores how a diabolical act can trigger equal and opposite reactions, fracturing opinions across society. Rather than offering easy answers, Daayra encourages deeper thought, raising questions that will linger long after the story unfolds. Meghna Gulzar brings her trademark sensitivity and narrative precision to the film, crafting a story that is as intellectually arresting as it is emotionally resonant. Anchored by compelling, nuanced performances from Kareena Kapoor Khan and Prithviraj Sukumaran, Daayra is further strengthened by a powerful ensemble cast that adds depth and gravitas to its world. Daayra unites Junglee Pictures with Pen Studios, led by Dr Jayantilal Gada. The movie has been co-written by Yash and Sima alongside Meghna. Following Talvar and Raazi, Daayra marks Meghna Gulzar’s third collaboration with Junglee Pictures, continuing a creative partnership known for delivering cinema that sparks conversation and critical acclaim. With filming now complete, the team looks forward to bringing this sharp, thought-provoking story to audiences in cinemas in 2026. Also Read: Kareena Kapoor Khan and Prithviraj Sukumaran wish Daayra director Meghna Gulzar on her birthday。这种新的分子癌症治疗方法依赖于一种特定的分子，它可以寻找围绕癌细胞的酸性环境。但是，为了使细胞有足够的酸性，它们不能是“冷”的肿瘤，这种肿瘤几乎没有免疫活性。这就是被称为STING激动剂的药物发挥作用的地方。

B | 这些药物使肿瘤“燃烧”起来，允许免疫系统对其作出反应。然而，找到"冷"癌细胞可能很困难。这就是新的分子癌症疗法发挥作用的地方。研究人员本月在《肿瘤学前沿》（Frontiers of Oncology）杂志上发表了一项关于该分子的研究。根据该研究，该分子被称为pH值低的插入肽（pHLIP），它被吸引到酸性环境。通过使用该分子引导药物到肿瘤和癌细胞，他们能够将它们踢出"寒冷"的肿瘤范围，推动免疫系统进行反击。然后，他们可以使用免疫检查点抑制剂来有效地移除使免疫系统不至于用力过猛的自然刹车。这种分子癌症治疗方法让免疫系统更长时间地对抗癌症。这是一个双重的系统，基本上允许研究人员准确地引导药物到它们需要的地方。近年来，我们已经看到越来越多像这种新的分子癌症治疗方法这样的靶向选择出现了。一种针对癌细胞的病毒也一直在进行，我们甚至看到研究人员在测试一种能杀死皮肤癌的凝胶。在测试分子癌症治疗方法时，研究人员将pHLIP与STING激动剂耦合在一起，然后对20只患有结肠直肠肿瘤的小鼠进行治疗。